Uterine double-conditional inactivation ofSmad2andSmad3in mice causes endometrial dysregulation, infertility, and uterine cancer
نویسندگان
چکیده
منابع مشابه
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.
Etiology of endometrial cancer (EMC) is not fully understood. Animal models with rapidly and spontaneously developing EMC will help explore mechanisms of cancer initiation and progression. Pten(+/-) mice are currently being used as a model to study EMC. These females develop atypical endometrial hyperplasia of which approximately 20% progresses to EMC. In addition, tumors develop in other organ...
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Congenital anomalies of the Müllerian ducts especially uterine abnormalities can affect negatively the different stages of fertility interfering with sperm migration, embryo implantation, normal placentation, fetal growth and achievement of a successful pregnancy. They are present in 2-10% of all women, three times greater in patients with recurrent pregnancy loss and lead to infertility and ad...
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Background Earlier it was believed that uterine fluid (UF) or secretions are not relevant after the embryo implantation in humans. However, recent reports suggest that uterine secretions continue to play important role till the first trimester of human pregnancy. Evidences also suggest that uf mirrors endometrial functions or dysfunctions. Considering the relevance of uf in endometrial function...
متن کاملProgesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer.
The expressions of two isoforms of human progesterone receptor (PR) are under the control of the two different promoters. Recent studies revealed differences between these isoforms, PRA and PRB, in their expression and function in endometrial cells. Aberrant methylation of normally unmethylated CpG islands has been associated with inactivation of several genes in human cancers. In this study, w...
متن کاملO-32: Endometrial Secretome and Its Role in Uterine Functions
Background Earlier it was believed that uterine fluid (uf) or secretions are not relevant after the embryo implantation in humans. However, recent reports suggest that uterine secretions continue to play important role till the first trimester of human pregnancy. Evidences also suggest that uf mirrors endometrial functions or dysfunctions. Considering the relevance of uf in endometrial function...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1806862116